F2RL1 and asthma: This finding may represent PAR-2 hypersensitivity of asthmatic-derived eosinophils, or an up regulation of PAR-2 in asthmatic suggesting a direct association of PAR-2, asthma, and these immune cells.[27] The observed outcomes proposed that these granulocytes in asthmatics are affected differently by PAR-2 stimulus than the non-asthmatic derived.