Intuitively, we expect that cell populations actively competing with one another may be less likely to coexist within the same region of a tumour and that their coexistence may indicate a cooperative relationship, as Snuderl et al. [21] suggest after finding intermingled sub-populations of EGFR and PDGFRA amplified sub-populations in a small number of GBM samples. Here, PDGFRA is linked to glioblastoma.