In all previous simulations presented in this paper we assumed that the mutation events leading to the establishment of EGFR and PDGFRA amplified sup-populations in our model occurred in the center of the growing tumour; this was a reasonable place to explore the effects of selection advantages and timing of mutations from, since it is where most proliferation is taking place in our model in the early phases of tumour growth and, therefore, where we may expect more mutations to appear. This evidence concerns the gene EGFR and neoplasm.