For example, the proportion of the tumour with only EGFR amplified, AE, is calculated as(3.1)AE(t)=∫0LH(E(x,t)−0.1K)H(0.1K−P(x,t))dx∫0LH(E(x,t)+P(x,t)+N(x,t)−0.1K)dx,(3.2)≈Number of mesh points with E>0.1K and P<0.1KNumber of mesh points with T>0.1K,where H(·) is the Heaviside step function. The gene discussed is EGFR; the disease is neoplasm.