For example, a study reconstructing the phylogeny of GBMs suggests that EGFR amplification is a mutation that arises earlier than amplification of the PDGFRA gene [9], while other studies have found that tumours with EGFR amplified are more invasive, which could indicate that EGFR amplified cells themselves are more invasive [14, 15]. The gene discussed is PDGFRA; the disease is neoplasm.