In addition, murine bone marrow chimaera experiments showed that OPC is controlled by NLRC4 functioning in the stromal and epithelial compartment and by NLRP3 functioning in hematopoietic-derived inflammatory cells, whilst protection against disseminated fungal infection was driven by NLRP3 functioning in both hematopoietic and stromal cell lineages [18]. The gene discussed is NLRP3; the disease is fungal infectious disease.