Selective calcium channel blockers with mainly vascular effects (C08C), for example, those indicated for the treatment of hypertension, such as angiotensin-converting enzyme (ACE) inhibitors (C09A-B; Fig 3) and angiotensin II receptor blockers (C09C-D) were weakly associated with an increased mortality rate (HR ranging from 1.4 to 1.7). The gene discussed is ACE; the disease is Hypertension.