MYH11 and atherosclerosis: In contrast to previous work (22, 23, 36), a recent intriguing paper employing a similar Myh11-CreERT SMC fate-mapping system and single-cell RNA-Seq approaches in the setting of atherosclerosis reported that mature SMCs transition to “fibromyocytes” rather than macrophages to contribute to fibrous cap formation and lesion stability (42).