APLN and peripheral vascular disease: Studies on the effects of apelin and Elabela on the cardiovascular system showed that they: i) contribute to the formation of heart and angiogenesis in the embryogenic period; ii) have inotropic effects; iii) cause vasodilatation in both systemic and pulmonary vascular systems; iv) cause reduction or deceleration in diseases, leading to cardiac hypertrophy and fibrosis; v) reduce peripheral vascular disease; and vi) improve heart failure and myocardial infarction clinic[3].