SLC9C1 and cancer: In particular, NHEs are prime drug targets for cancer therapies (Stock & Pedersen, 2017; Pedersen & Counillon, 2019), since tumour cells typically upregulate NHE expression to re‐alkalinize intracellular pH in response to the “Warburg effect” (Cardone et al, 2005; Parks et al, 2013), i.e. as metabolic preference for oxidative glycolysis leads to intracellular acidification.