We found AR down‐regulated the expression of circRNA7, up‐regulated the expression of miR‐7‐5p and suppressed VM formation in HCC ShcircR7 blocked VM formation and the expression of VE‐cadherin and Notch4 that had been increased by shAR in HCC, and shmiR‐7‐5p rescued VM formation and expression of VE‐cadherin and Notch4 that had been decreased by oeAR in HCC. This evidence concerns the gene CDH5 and hepatocellular carcinoma.