Analysis of affected individuals belonging to high‐risk pedigrees has long been a powerful design for identification of rare cancer predisposition genes and variants in Utah (e.g., BRCA1 [OMIM 113705], BRCA2 [OMIM 600185], CDKN2A [OMIM 600160], GOLM1 [OMIM 606804], APC, PTEN [OMIM 601728]). Here, PTEN is linked to cancer.