HSD17B12 and colorectal carcinoma: We observed that knockdown of YY1 abrogated the different effects of the rs10838164 C allele and T allele on the transcriptional activity of HSD17B12. Additionally, rs10838164 C>T enhanced the binding affinity of YY1 to HSD17B12. The HSD17B12 mRNA expression levels changed in the same direction with YY1 knockdown or overexpression in CRC cells.