We observed that knockdown of YY1 abrogated the different effects of the rs10838164 C allele and T allele on the transcriptional activity of HSD17B12. Additionally, rs10838164 C>T enhanced the binding affinity of YY1 to HSD17B12. The HSD17B12 mRNA expression levels changed in the same direction with YY1 knockdown or overexpression in CRC cells. The gene discussed is YY1; the disease is colorectal carcinoma.