SNCA and Parkinson disease: An important mechanism for degeneration in Parkinson’s disease is thought to be dysfunction in the autophagy-lysosome pathway (ALP) (Pan et al., 2008), particularly within its subpathway, chaperone-mediated autophagy (Alvarez-Erviti et al., 2011), with lysosomal malfunction leading to accumulation of alpha-synuclein (Cuervo et al., 2010; Lawrence and Zoncu, 2019).