Higher IL-4, IL-5, IL-13 (106), and beta-casomorphin-5 (107) in colostrum, and higher levels of IL-4 (108), lower levels of TGF-β1 (109, 110), TGF-β2 (111), IL-10 (108) and proteome (including protease inhibitors and apolipoproteins) (112) in HM were found in women with history of allergic disease compared with non-allergic women. This evidence concerns the gene IL5 and allergic disease.