NPPB and hydrops fetalis: Similarly, CpcPH-HFpEF patients were found to have about 1.8-fold higher levels of NT-proBNP compared to IpcPH-HFpEF patients, which was associated with an increased frequency of HF hospitalizations, reduced RV-vascular coupling (as measured by the ratio between tricuspid valve annular plane systolic excursion and PASP; TAPSE/PASP), impaired RV function, and severely depressed exercise capacity (43).