This may be due to the high prevalence of obesity in HFpEF populations, as disproportionately low BNP and NT-proBNP levels have been reported in obese patients, which may be related to the mechanisms involving natriuretic peptide degradation in adipose tissue, insulin resistance, and enhanced pericardial restraint (32, 34–37). The gene discussed is NPPB; the disease is Obesity.