Consistently, the knockout of HMOX1 suppresses, whereas the overexpression of HMOX1 promotes, ferroptotic cancer cell death induced by erastin (Kwon et al., 2015) or BAY 11-7085 (NFKB inhibitor alpha [NFKBIA/IKBA] inhibitor) (Chang et al., 2018). The gene discussed is NFKBIA; the disease is cancer.