Like the knockdown of autophagy-related 5 (ATG5) or ATG7, the knockdown of NCOA4 also blocks ferritin degradation and suppresses erastin-induced ferroptosis in fibroblasts and pancreatic cancer cells, whereas the overexpression of NCOA4 promotes ferroptosis by degrading ferritin (Hou et al., 2016). This evidence concerns the gene ATG5 and familial pancreatic carcinoma.