TSC1 and infection: To further address the relationship between mTORC1 overactivation and NLRP3 expression during V. vulnificus infection, we infected the BMMφs from Tuberous Sclerosis Complex 1 (TSC1)flox/flox LysM-Cre+ mice (TSC1 KO) and C57BL/6J (wild-type, WT) mice with 2 multiplicity of infection (MOI) V. vulnificus. Infected TSC1 KO BMMφs increased the production of mature IL-1β in response to V. vulnificus challenge (Figure 3E).