Interestingly, as shown in Figure 1A, only one gene (IL-1β) that responded to V. vulnificus infection was overlapping among tuberculosis, salmonella infection, legionellosis, leishmaniasis, HCMV infection, measles, and influenza A. Furthermore, only six genes (Nlrp3, Cd36, Ccl3, etc.)overlapped in the core of the gene sets related to defense response, host response to the bacterium, innate immune response, IL-1β production, and regulation of the cellular metabolic process (Figure 1A). This evidence concerns the gene NLRP3 and leishmaniasis.