CD274 and neoplasm: For instance, inhibition of prolactin receptor signaling by diphenylbutylpiperidine antipsychotic drugs reduces the growth of PDAC (Dandawate et al., 2019); prostaglandin regulates tumor-associated immunosuppression by inducing MDSC and Treg differentiation, macrophage polarization from M1 to M2, and production of PD-L1 (Wang and DuBois, 2018).