In preclinical models, chronic stress is sufficient to promote tumor growth and angiogenesis in ovarian carcinoma (Thaker et al., 2006), breast cancer lung colonization (Chen et al., 2018), EGFR inhibitor resistance in non-small cell lung cancer (NSCLC) (Nilsson et al., 2017), and therapy-induced anticancer immunosurveillance (Yang H. et al., 2019). Here, EGFR is linked to neoplasm.