TSC22D3 and cancer: Recent experimental studies have elucidated that stress-induced glucocorticoid surge and Tsc22d3 upregulation in dendritic cells subvert chemotherapy or immunotherapy-induced anticancer immunosurveillance; in cancer patients, there is a close correlation among plasma cortisol levels, TSC22D3 expression in circulating leukocytes and negative mood (Yang H. et al., 2019).