Circadian disruption promotes cholestasis, peripheral clock disruption, and sympathetic dysfunction, which lead to activation of the well-known liver tumor promoter, constitutive androstane receptor (CAR), resulting in progression of non-alcoholic fatty liver disease (NAFLD)-induced hepatocarcinogenesis (Kettner et al., 2016). Here, NR1I3 is linked to metabolic dysfunction-associated steatotic liver disease.