In addition, inducible RNAi to specifically suppress Orai1 expression in the Drosophila heart resulted in significant delays in post-embryonic development, premature death in adults, and impaired cardiac function due to myofibril disorganization consistent with dilated cardiomyopathy (Petersen et al., 2020). This evidence concerns the gene ORAI1 and dilated cardiomyopathy.