ORAI1 and cardiac hypertrophy: We also found that after chronic pressure overload, cardiomyocyte-specific dn-Orai1R91W mice (C-dnO1), or in vivo JPIII-treated (a new selective Orai1 inhibitor) mice were protected from left ventricular systolic dysfunction and from interstitial fibrosis deposition, even if increased cardiac hypertrophy was observed.