In a mouse model and cultured cardiomyocyte model treated with AngII or PE, gastrodine, a polyphenol with anti-inflammatory properties used in traditional Chinese medicine, is protective against the development of cellular and cardiac hypertrophy by attenuating the SOCE and reducing the expression of STIM1 and Orai1 (Zheng et al., 2017). This evidence concerns the gene ORAI1 and cardiac hypertrophy.