Several lncRNAs overexpressed in cancer, notably SNHG17 in colorectal and gastric cancer, SH3PXD2A-AS1 in colorectal cancer, or LncRNA00511 in non-small cell lung carcinoma, were shown to downregulate p57 via their interaction with EZH2, the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2), a methyltransferase that causes chromatin condensation (Sun et al., 2016; Ma et al., 2017, 2018; Zhang et al., 2019a). This evidence concerns the gene EZH2 and colorectal cancer.