For instance, BWS patients are predisposed to tumor development (Weksberg et al., 2010) and decreased p57 expression is observed in many types of tumors, including in gastric, colorectal, pancreatic, pulmonary, and mammary carcinomas, as well as in leukemia (Li et al., 2003; Pateras et al., 2009; Borriello et al., 2011; Kavanagh and Joseph, 2011; Weis et al., 2015). This evidence concerns the gene CDKN1C and Beckwith-Wiedemann syndrome.