CDKN1C and gastric cancer: NSUN2 (NOP2/Sun RNA methyltransferase 2), the main enzyme catalyzing 5-methylcytosine (m5C) formation, is upregulated in gastric cancer and promote cell proliferation and tumorigenesis via m5C methylation of the p57 mRNA, repressing p57 expression (Mei et al., 2020).