Interestingly, MKK7 transcription critically depends on the deacetylation of the transcription factors SP1 and Kruppel-like factor-5 (KLF5) by HDAC4, the inhibition of which is paramount in suppressing the oncogenic JNK/c-Jun cascade involved in glioma cells (Wang et al., 2019). This evidence concerns the gene KLF5 and central nervous system cancer.