Panobinostat-induced downregulation of meiotic recombination 11 homolog (MRE11) enhances radio-sensitization of bladder cancer cells by promoting MRE11 ubiquitination that relies on the upregulated E3 inhibitor of apoptosis protein 2 (cIAP2) (Nicholson et al., 2017). Here, MRE11 is linked to urinary bladder cancer.