Conversely, SIRT3 and SIRT6 also act as tumor suppressors, restricting aerobic glycolysis in cancer cells through destabilization of hypoxia inducible factor 1 subunit alpha (HIF-1α) and inhibition of glycolytic kinases, respectively (Finley et al., 2011; Sebastian et al., 2012). This evidence concerns the gene HIF1A and cancer.