Outside the four signaling pathways mentioned in a previous article, a new study found that transgelin could bind to poly(ADP-ribose) polymerase-1 (PARP1) and regulate downstream genes, which are mainly involved in the Rho signaling pathway, initiate cytoskeletal remodeling, and induce CRC metastasis (Lew et al., 2020). The gene discussed is TAGLN; the disease is colorectal carcinoma.