Zhou H. M. et al. (2016) observed that overexpressing transgelin in CRC cells led to an increase in the number and size of lung metastases in a mouse tail vein injection model, but attenuation of transgelin expression decreased both parameters in the same model. In addition, proteomic studies of T-1 frequently indicate up-regulation in aggressive late-stage disease (Elsafadi et al., 2020). Here, TAGLN is linked to colorectal carcinoma.