JMJD3 participated a wide range of disease processes including immune diseases (Chen et al., 2018), cancer (Ramadoss et al., 2012), infectious diseases (Sun et al., 2019), aging related diseases (Salminen et al., 2014; Tamgue and Lei, 2017), and development diseases (Park et al., 2014). This evidence concerns the gene KDM6B and immune system disorder.