Mahati et al. (2017) observed that TMPRSS4 and CLDN1 were remarkably upregulated in HCC tissues, while overexpression of CLDN1 induced EMT and CSC behaviors via TMPRSS4 in HCC. Mechanistically, Ou et al. (2019) provided evidence that Frizzled 2 (FZD2) is a driver of EMT and CSC properties in HCC. Here, FZD2 is linked to hepatocellular carcinoma.