CD44 and hepatocellular carcinoma: Deregulation of miR-200b was involved in regulation of LCSCs, the miR-200b–ZEB1 circuit was found to regulate diverse LCSCs (Tsai et al., 2017), and miR-219 down-regulated E-cadherin via its mRNA 3′UTR, thus playing a role in the sensitivity of HCCs to sorafenib (Si et al., 2019), miR-137 expression was upregulated in CD44-positive CSCs and found to be associated with a significantly shorter survival periods for HCC patients (Sakabe et al., 2017).