HIF1A and neoplasm: Excessive consumption of glutamine caused by glutamine addiction can result in local deprivation of glutamine outside the cell, which can induce macrophages to secrete IL23 through activation of hypoxia-inducible factor 1α (HIF1α), and IL23 activates the proliferation of Treg cells, promotes the expression of IL10 and TGF β, thereby inhibiting cytotoxic lymphocytes from killing tumor cells and coordinating immune escape (59).