We found that the inhibitory effect of PI3K-AKT-mTOR signal significantly reduced glycolysis and fatty acid oxidation and inhibited tumor growth, while phospholipase A2 (PLA2) can mobilize lysophospholipids and free FA to maintain fatty acid oxidation and oxidation phosphorylation, which reduces the inhibitory effect of PI3K-AKT-mTOR signaling, provides a new strategy for cancer treatment. Here, AKT1 is linked to cancer.