NFKB1 and breast carcinoma: In addition, Chen Weilong et al. found that during the taxane-containing chemotherapy, the CC motif chemokine ligand 20 (CCL20) was significantly elevated, which is activated by protein kinase Cζ (PKCζ) or p38 mitogen Protein kinase (MAPK) -mediated NF-κB activation to promote self-renewal and maintenance of CSC or breast cancer stem-like cells, while NF-κB activation increases CCL20 expression, forming a positive feedback loop between the NF-κB and CCL20 pathways, providing continuous momentum for chemo-resistance in breast cancer cells (64–66).