Based on our findings in this study, we propose a working model to illustrate the interplay of PHF20 and WDR5 modulates the WISP1 promoters, leading to WISP1 activation, which in turn results in the subsequent induction of BGN. This increases and stabilizes the β-Catenin protein levels and promotes GBM malignant transformation (Figure 6). The gene discussed is CCN4; the disease is glioblastoma.