To explore whether BGN and WISP1 act in concert in GBM through their positive feedback loop, we determined the expression correlation between BGN and WISP1 by qPCR and Western-blotting analyses, and found both the mRNA and protein levels of BGN decreased in WISP1 KD glioma cells (Figures 4B,C). The gene discussed is CCN4; the disease is central nervous system cancer.