Ablation of PHF20 inhibited the proliferation and malignancy, while ectopic expression of PHF20 enhanced the expression of WISP1 and BGN, resulting in the formation of a complex between WISP1 and BGN that regulated the degradation of β-Catenin, suggesting that PHF20 is a pivotal factor of GBM development. Here, BGN is linked to glioblastoma.