TP53 and cancer: The researchers identified that both the protein phosphatase 2A (PP2A) B subunit B55α-E3 ubiquitin ligase identified by differential display (EDD)-p53 pathway and I-kappa-B-kinase β (IKKβ)-p53 signaling axis are essential for cancer cell survival and tumor growth in response to glutamine deprivation (38, 39).