TWIST1 and pancreatic neoplasm: A recent study demonstrated that arginine deprivation inhibited the adhesion, invasion and migration of pancreatic cancer cells through decreasing the expression of Snail, Slug, Twist as well as matrix metalloproteinases (MMPs) MMP-1 and MMP-9 and increasing E-cadherin expression, which is mediated by regulation of the PI3K/AKT/GSK3β signaling axis (102).