A recent study suggests that methylation on arginine 248 inhibits MDH1 catalytic activity and dimerization by coactivator-associated arginine methyltransferase 1 (CARM1), and KRAS suppresses CARM1-mediated MDH1 methylation, contributing to glutamine metabolism in pancreatic cancer (19). The gene discussed is CARM1; the disease is familial pancreatic carcinoma.