Glutamine-derived glutamate supports the viability and proliferation of cancer cells by replenishing tricarboxylic acid (TCA) cycle intermediate α-ketoglutarate (α-KG) that is mediated by either glutamate dehydrogenase (GLUD) or aminotransferases alanine aminotransferase (also known as glutamate-pyruvate transaminase, GPT) and aspartate aminotransferase (also known as glutamate-oxaloacetate transaminase, GOT) (8). The gene discussed is GPT; the disease is cancer.