EGFR and head and neck squamous cell carcinoma: However, a phase II clinical trial (14) of Romidepsin, another HDACi, performed in 14 patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) including two primarily localized in oral cavity, six in oropharynx, two in hypopharynx, and four in larynx showed no significant clinical benefit despite high acetylation level of histone H3, reduced Ki67 staining, and decreased expression of HDAC6, 9, and EGFR.