Almeida et al. (17) reported that cisplatin-resistant HNSCC cells (HN6, HN13, Cal27, UM-SCC17B, UM-SCC74A) had active signaling of nuclear factor kappa B (NF-κB), which promoted chemo-resistance of HNSCC by inducing histone deacetylation, reducing BRCA1 level, and thus enhancing genomic instability. Here, NFKB1 is linked to head and neck squamous cell carcinoma.