Also, Jiao et al. in 2012 observed plasma levels of sTNF-αRII, sTNF-αRI, TNFβ, IFNα2, sIL-6R, MCP1, epidermal growth factor (EGF), granulocyte colony-stimulating factor (G-CSF), and VEGF significantly increased; in addition, sRAGE level was decreased in 158 cases with colorectal adenoma (147). This evidence concerns the gene EGF and colorectal adenoma.