However, Ichikawa et al. indicated that S100A8/A9–RAGE and carboxylated glycan interaction activates phosphorylation of ERK1/ERK2 and SAPK/JNK MAPK in colon tumor cells, but not significant p38 phosphorylation, which led to elevation of Slc39a10, Cxcl1, Ccl5, Enpp2, Ccl7, Lcn2, Zc3h12a, and other genes, and stimulates recruitment of leukocytes, angiogenesis, migration of tumor cells, wound soothing, and creation of premetastatic microenvironment (109). This evidence concerns the gene S100A8 and colonic neoplasm.