MMP9 and Familial prostate cancer: Moreover, H&E staining and quantitative analysis of the metastatic nodules in lungs showed that celecoxib treatment significantly reduced the number of metastatic nodules in the lungs of prostate cancer patients induced by of PKM2 overexpression (Figures 6B,C), while N-cadherin, vimentin, and MMP9 were also markedly inhibited in response to celecoxib treatment (Figures 6D,E).