BRCA1 and serous adenocarcinoma: Soslow et al. studied tumors from patients with germline BRCA1/2 mutations in addition to tumors with somatic BRCA1/2 mutation or promoter hypermethylation and found that BRCA1-associated high-grade serous carcinomas exhibit high mitotic rates, increased TILs, geographic/comedo-type necrosis, and non-traditional architectural patterns including Solid, pseudo-Endometrioid, and Transitional-like (SET) features.