In fact, analysis of RMS samples revealed oxidative stress-induced genomic mutations that enhance RMS cell survival against oxidative damage whereas combinational targeting of the major antioxidative pathways up-regulated in RMS, the thioredoxin (TRX) and glutathione (GSH) synthesis pathways, using GSH-depleting agents and TRX-reductase inhibitors seems to induce cancer cell death (55, 64). The gene discussed is TXN; the disease is cancer.