BTRC and colorectal carcinoma: It is known that Wnt signaling plays an essential part in the early stage of CRC, but in this study, we address that miR-224 might mediate BTRC expression and control cell migration and invasion by interfering Wnt pathway, which is analogous to our previous study that the Wnt/β-catenin pathway mediated by hsa-miR-650 could affect CRC cell migration and invasion (Zhou et al. 2017).