To understand the CD8+ T cell-intrinsic role of EZH2 in the antitumoral immune response, an adoptive transfer model was exploited, utilizing the B16 melanoma model in conjunction with T cells bearing a transgenic TCR (Vα1Vβ13) recognizing the melanoma glycoprotein gp10025−33 (Pmel) (44). The gene discussed is EZH2; the disease is melanoma.