This gain-of-function amplification drives MYC expression downstream of NOTCH1 in T-ALL and helps to connect MYC and Notch signaling in driving oncogenesis; a different mechanism but with the same effect as the previous mentioned study in which an impaired CTCF binding (due to reduced chromatin accessibility) leads to MYC enhancer hijacking (44). Here, NOTCH1 is linked to acute lymphoblastic leukemia.