SDC3 and cancer: There is some evidence that Sdc-3 is expressed in the TME and several cancer cell lines, including bladder cancer (23), hepatocellular carcinoma (22, 24), mammary carcinoma (25), ovarian cancer (19, 20), pancreatic cancer (26), prostate carcinoma (27), renal cell carcinoma (12, 28), and several glioma cell lines (29).