Skin melanoma, the solid tumor type with the highest ratio of expression of Sdc-3 on malignant versus normal tissue (Figures 1A,C), shown a positive correlation with the hypoxia signature for both SDC3 (Figures 2A,C) and SDC4 (Figures 2B,C), while DLBC, a non-solid tumor, presented no significant correlation (Figures 2A–C). Here, SDC3 is linked to cutaneous melanoma.