Our study reveals a progressive AM transcriptome from the Scgb1a1 WT mice at weaning (4 week), puberty (8 week), early adult (12 week), and middle age (40 week) whereas that in Scgb1a1 deficiency resembles the disorder of SCGB1A1 depletion induced by smoking, COPD and other types acute and chronic lung injuries in the humans. Here, SCGB1A1 is linked to chronic obstructive pulmonary disease.