The retinal microvasculature is progressively damaged by the disease, resulting in various events such as retinal ischemia, upregulation of hypoxia inducible factor-1 (HIF-1), and vascular endothelial growth factor (VEGF) secretion, possibly progressing to PDR, which is diagnosed according to the presence of vascular lesions (e.g., preretinal or vitreous hemorrhages or neovascularization) (4). This evidence concerns the gene VEGFA and hemorrhage.