Given that the tumors were inoculated from the same cell culture at the same time and, and that in all instances the cell inoculations into WT mice yielded tumor growth, we are led to conclude that the underlying T-cell activation thresholds in the dKO mice differ significantly between WT and PD-1 KO situations, and that the dKO animals likely rejected the implanted tumors more efficiently (Figure 3F and (Supplementary Figure 6B). The gene discussed is PDCD1; the disease is neoplasm.