TIGIT and neoplasm: As shown in Figure 2, the CT26 tumor-bearing mice treated with the 9E9 antibody followed by anti-TIGIT:mIgG2a displayed diminished anti-tumor efficacy when compared to the anti-TIGIT:mIgG2a + isotype control treatment group, demonstrating that the interaction of the anti-TIGIT:mIgG2a antibody with FcγRIV is of importance for optimal anti-tumor efficacy observed with that antibody (Figure 2).