In addition, the novel approaches adopted in the past 5–10 years of combining CPZ and EAE (169–171) and diphtheria toxin-induced oligodendrocytosis (52, 173–177) compared to the over 70 years of research on EAE (14) and ~60 years on CPZ (180) have yet to reveal their role in promoting a better understanding of the pathoetiology of MS. The gene discussed is CPZ; the disease is myeloid sarcoma.