NTN1 and type 2 diabetes mellitus: Luo et al. performed in vivo targeting of the NTN1 gene, whose overexpression is associated with type 2 diabetes (T2D) and monocyte/macrophage-specific expression, with no off-target effects and an editing efficiency of 10.1% at a dose of 1 mg/kg and of 19.6% at 2 mg/kg as compared with 1.2 and 2.3% for indels detected in neutrophils, respectively (89).