MSP-RON antagonizes inflammatory response induced by oxidized low-density lipoproteins and LPS via activating the AMPK signaling pathway (46). Activation of RON improves diet-induced fibrosis in non-alcoholic fatty liver mice, and RON knockout mice exhibit higher levels of inflammatory cell infiltration, collagen, ECM remodeling proteins, and profibrotic cytokine expression (47). The gene discussed is MST1; the disease is non-alcoholic fatty liver.