Beyond the combination of RT and ICB, there have been remarkable advancement in the use of anti-angiogenesis agent in treatment for HCC reported by the phase III IMbrave150 trial, which demonstrated superiority in terms of ORR, OS, and PFS in HCC patients treated with atezolizumab (anti-PD-L1) and bevacizumab (anti-VEGF-A) versus patients treated with sorafenib (21). The gene discussed is VEGFA; the disease is hepatocellular carcinoma.