In the present study, increased decidual NLRP3 inflammasome response was observed in preeclampsia without FGR, and this could indicate that the decidual tissue may respond more to the increased maternal danger signals, including pro-atherogenic lipid profile, circulating levels of inflammatory mediators, such as HMGB1 and uric acid, and predisposition to inflammation. Here, NLRP3 is linked to preeclampsia.