The acute form of PCM shows a mixed Th2/Th9 response: increased levels of IL-4, IL-5, IL-9, IL-10, TGF-β, and IL-27; low production of IFN-γ and TNF-α; and high levels of specific IgG4 and IgE antibodies. This evidence concerns the gene IL5 and paracoccidioidomycosis.