IL18 and bacterial infectious disease: Similarly to our results, the mutant allele/genotype of IL18-607 C/A is also associated with more severe outcomes in other infectious diseases: higher virus shedding of the severe acute respiratory syndrome-associated (SARS) coronavirus in Taiwan, lipodystrophy syndrome on HIV-positive Brazilian individuals, immune restoration disease on HIV–tuberculosis coinfected Indian patients, bacterial infections after liver transplantation in China, and hepatitis C–related hepatocellular carcinoma in Egypt (63–67).