IL18 and infection: MyD88-deficient mice show a more severe disease after 8 weeks of infection with low levels of IL-12, and a protective role in murine pulmonary PCM was shown in the NLRP3 inflammasome, associated with IL-1β and IL-18 secretion and expansion of Th1 and Th17 cells and suppressive control of T-reg cells (7, 21).