Moreover, in Brazilian patients with PCM, reports of polymorphisms on IL-4 and IL-12Rβ1 genes have shown the relevance of IL4-590 C/T and IL12RB1 641 A/G SNPs in association with infection or clinical forms, contributing to a better understanding of the immunopathogenesis of this disease (30, 31). Here, IL12RB1 is linked to paracoccidioidomycosis.