M1 macrophages are able to: (i) release pro-inflammatory cytokines such as IL-12, IFN gamma, IL-1, IL-23, and iNOS; (ii) reeducate the DC and CD4 + T cells; and (iii) activate CD8 + T cells and, as a result, promote an immune response against the tumor and prevent tumor progression. The gene discussed is CD4; the disease is neoplasm.