Additionally, the reduction in disease symptoms in H. polygyrus-infected mice correlated with reduced CD4+ T cell (Figure 1C, Supplementary Figure 1A) and macrophage (Figures 1D,E, Supplementary Figures 1Band2) infiltration into the spinal tissue, confirming that parasite infection impedes EAE disease progression in the CNS. This evidence concerns the gene CD4 and parasitic infectious disease.