Previous studies have shown that TSK impacts systemic cholesterol homeostasis by lowering circulating high-density lipoprotein cholesterol and cholesterol efflux capacity, and acts as a blood biomarker of liver stress linking non-alcoholic steatohepatitis (NASH) and the development of atherogenic dyslipidemia and atherosclerosis (21, 22). This evidence concerns the gene TSKU and metabolic dysfunction-associated steatohepatitis.