Again, our health insurance data could not offer the lab data of thyroid function such as TSH, FT4, or T3 and thyroid anti-body such as anti-TPO, and we only used the other clues to approve the association between hemorrhoid and HT including the status of hypothyroidism, subclinical hypothyroid disease, or euthyroidism. The gene discussed is TPO; the disease is hypothyroidism.