Functioning in a paracrine fashion within adipose tissue, locally produced PGD2 may trigger a variety of adipose housekeeping mechanisms with potential impact on metabolic syndrome evasion, including (i) down-regulation of leptin production (66), secretion of Type 2 cytokines IL-5 as well as IL-4 by ILC2s (67, 68), activation of adipose eosinophils (16) and/or polarization of macrophages toward a M2 anti-inflammatory state (69). Here, LEP is linked to metabolic syndrome.