MCI is most commonly referred to as a degenerative etiology (i.e., Alzheimer's disease [AD], frontotemporal dementia, dementia with Lewy bodies), but vascular (i.e., vascular cognitive impairment), psychiatric (e.g., depression), genetic (APOE and TOMM40 genes) and other medical conditions (e.g., uncompensated heart failure, poorly controlled diabetes mellitus, or chronic obstructive pulmonary disease) can also contribute to the determination of cognitive impairment (9, 10). This evidence concerns the gene APOE and Alzheimer disease.